What defines a closed chain of custody?

A closed chain of custody is defined by secure handling of ready-to-use formulations. This term refers to a systematic approach where the possession and handling of a substance, particularly hazardous materials or chemicals, is closely controlled and documented. The goal of a closed chain of custody is to ensure that all materials are accounted for, tracked throughout their lifecycle, and subject to specific safety and regulatory protocols.

In this context, the secure handling aspect emphasizes the importance of limiting access to the materials to authorized personnel only, maintaining their integrity and safety, and ensuring compliance with safety standards and regulations. This approach helps prevent accidents, misuse, and potential hazards associated with chemical handling in various settings, such as laboratory, industrial, or field environments.

The other options do not align with the concept of a closed chain of custody as they suggest elements of open access or unregulated handling of materials, which contradict the core principles of secure management and accountability that a closed chain entails.